Pair Name	Kaempferol, Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Activity	PIK3CA	hsa5290
	Down-regulation	Expression	TYMS	hsa7298
In Vitro Model	HCT 8	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_2478
	HCT 116	Colon carcinoma	Homo sapiens (Human)	CVCL_0291
In Vivo Model	To generate HCT116 xenografts in BALB/c nude mice, 3 × 106 HCT116 cells were subcutaneously injected into the left and right flanks of each mouse.
Result	The present study demonstrated that kaempferol has a synergistic effect with 5‑FU by inhibiting cell proliferation and inducing apoptosis in colorectal cancer cells via suppression of TS or attenuation of p‑Akt activation. The combination of kaempferol and 5‑FU may be used as an effective therapeutic strategy for colorectal cancer.

Pair Name	Kaempferol, Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Biological Phenomena	Inhibition-->Aerobic glycolysis
Gene Regulation	Down-regulation	Expression	HNRNPA1	hsa3178
	Down-regulation	Expression	HNRNPA2B1	hsa3181
	Down-regulation	Expression	PKM	hsa5315
	Down-regulation	Expression	PTBP1	hsa5725
In Vitro Model	HCT 8	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_2478
Result	Our data suggest that kaempferol may play an important role in overcoming resistance to 5-Fu therapy by regulating the miR-326-hnRNPA1/A2/PTBP1-PKM2 axis.